Dissertation
Circadian Rhythms and Brain Metabolism Across the Lifespan
Doctor of Philosophy (PhD), Washington State University
01/2020
Handle:
https://hdl.handle.net/2376/111149
Abstract
Circadian rhythms are daily patterns of physiology and behavior expressed in nearly every living organism. These rhythms can be desynchronized by abnormal timing of environmental light, which occurs in common human experiences like shift work, travel, and nighttime screen use. Circadian desynchronization (CD) has been associated with a multitude of negative health outcomes including metabolic syndrome, obesity, and depression. Although many studies describe the effects of CD on the brain and on whole-body metabolism, little is known about the neurometabolic consequences of desynchrony. This dissertation describes the effects of CD on lactate metabolism in the prefrontal cortex (PFC), a region of the brain which frequently displays dysfunction in individuals with mental health disorders. The chapters herein describe the changes in neurometabolism that are exerted by aging, mis-timed environmental light exposure, and CD during development. Together, the findings illustrate the devastating consequences of CD on neurometabolic function.
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Details
- Title
- Circadian Rhythms and Brain Metabolism Across the Lifespan
- Creators
- Naomi Kathleen Wallace
- Contributors
- Ilia N. Karatsoreos (Advisor)Ryan McLaughlin (Committee Member)Rita Fuchs Lokensgard (Committee Member)Russel Romeo (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Program in Neuroscience
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 204
- Identifiers
- 99900581808701842
- Language
- English
- Resource Type
- Dissertation