Dissertation
DEVELOPMENT AND OPTIMIZATION OF NOVEL BIOMANUFACTURING PLATFORMS FOR RAPID HIGH-DENSITY CULTURE AND REAL-TIME MONITORING OF T CELLS FOR NEXT-GENERATION CANCER IMMUNOTHERAPY
Washington State University
Doctor of Philosophy (PhD), Washington State University
07/2024
DOI:
https://doi.org/10.7273/000007042
Abstract
One of the most promising approaches to treating cancer is immunotherapy, which unlocks the full potential of the immune system. The treatment is still early in development, with many obstacles present that must be resolved to achieve widespread implementation. In this dissertation, a thorough investigation is undertaken which develops a new method to rapidly culture cells for immunotherapy in real time, while simultaneously examining the impact of the culture process on cell phenotype and providing real-time process readouts to assess condition of cells while they expand. The following work summarizes the findings of these studies and development of the novel platform, providing the results in the form in which they were originally submitted for publication, and offering new solutions to further improve the systems and apply them in relevant environments in industrial and medical settings.
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Details
- Title
- DEVELOPMENT AND OPTIMIZATION OF NOVEL BIOMANUFACTURING PLATFORMS FOR RAPID HIGH-DENSITY CULTURE AND REAL-TIME MONITORING OF T CELLS FOR NEXT-GENERATION CANCER IMMUNOTHERAPY
- Creators
- Brenden Fraser-Hevlin
- Contributors
- Bernard J Van Wie (Chair)William C Davis (Committee Member)Alla Kostyukova (Committee Member)Arda Gozen (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Chemical Engineering and Bioengineering
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 132
- Identifiers
- 99901152540601842
- Language
- English
- Resource Type
- Dissertation