Dissertation
DEVELOPMENT OF THE PLANE METHOD AND INVESTIGATION OF THE ACCEPTANCE, TRANSMITTANCE AND ION MOTION OF QUADRUPOLES
Doctor of Philosophy (PhD), Washington State University
01/2020
Handle:
https://hdl.handle.net/2376/112061
Abstract
Quadrupole mass analyzers separate ions by their mass to charge ratios (m/z). They do this by changing the stability environment of the mass spectrometer. Whenever there is a change to the stability environment there is also a change to the motion of each ion m/z inside of it. These changes may be subtle or dramatic. The change in stability and the process to carry out the change both affect ion motion. The motion and stability of ions regardless of their m/z is also affected by the way they are introduced to the mass analyzer. Even within a stable environment the motion of the ion can exceed the physical dimensions of the analyzer from the motion it had before it was introduced. Ion motion and introduction effects have been investigated extensively for conventional sine driven systems. Rectangular waveform driven systems alter stability instantly and have greater flexibility and control over the process. The flexibility and control of rectangular waveform systems has been demonstrated experimentally by some practitioners. The variety of pathways these systems can take to manipulate stability have demonstrated the many practical aspects and capabilities of rectangular waveform operation over conventional modes. Spreadsheet based stability diagrams have allowed immediate interpretation of duty cycle and frequency change and process of them on ion stability. However, they only account for the time averaged stability. They do not show changes to ion motion that result from change of duty cycle, frequency or introduction effects. Ion motion inside rectangular waveform systems has not been adequately explored. Given the dynamic capabilities of rectangular waveform systems and the many ways they can alter stability there is a need to satisfy this information gap. This work began the investigation of duty cycle and frequency effects on the motion and introduction of ions into rectangular waveform systems. Throughout this work, comparisons were made to sine driven systems. It significantly adds to the knowledge base for practitioners interested in the ion motion of conventional systems.
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Details
- Title
- DEVELOPMENT OF THE PLANE METHOD AND INVESTIGATION OF THE ACCEPTANCE, TRANSMITTANCE AND ION MOTION OF QUADRUPOLES
- Creators
- Adam Paul Huntley
- Contributors
- Peter T.A. Reilly (Advisor)Peter T.A. Reilly (Committee Member)Brian H Clowers (Committee Member)James A Brozik (Committee Member)Jeremy J Lessmann (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Chemistry, Department of
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 129
- Identifiers
- 99900581414101842
- Language
- English
- Resource Type
- Dissertation