Dissertation
INVESTIGATION OF THE EQUI MEROZOITE ANTIGEN (EMA) FAMILIES OF THEILERIA EQUI AND THEILERIA HANEYI
Doctor of Philosophy (PhD), Washington State University
01/2018
Handle:
https://hdl.handle.net/2376/111805
Abstract
Chapter 1 describes Theileria equi and Theileria haneyi and offers scientific background on these global equine parasites, focused on the equi merozoite antigen (EMA) protein families present in both species. Chapter 2 focuses on the development and validation of testing modalities using the EMA family members to determine the post-chemotherapeutic clearance of T. equi. This research examined results from 179 treated horses and demonstrated concordance between nested polymerase chain reaction targeting the ema1 gene and immunoblotting measuring declination in anti-EMA1 and anti-EMA2 antibodies to verify clearance of T. equi. Chapter 3 offers a comparison of the EMA families of both species including biochemical structure, putative function and genetic diversity. Chapter 4 offers conclusions about the EMA family and considerations for continued research in this field.
Metrics
12 File views/ downloads
34 Record Views
Details
- Title
- INVESTIGATION OF THE EQUI MEROZOITE ANTIGEN (EMA) FAMILIES OF THEILERIA EQUI AND THEILERIA HANEYI
- Creators
- Lauren Nicole Wise
- Contributors
- Donald P Knowles (Advisor)Stephen N White (Committee Member)Robert H Mealey (Committee Member)Kelly A Brayton (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- College of Veterinary Medicine
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 71
- Identifiers
- 99900581621201842
- Language
- English
- Resource Type
- Dissertation