Dissertation
MATERNAL VACCINATIONS PROVIDE ANTI-VIRAL ANTIBODY PROTECTION TO FETUS IN UTERO
Washington State University
Doctor of Philosophy (PhD), Washington State University
05/2024
DOI:
https://doi.org/10.7273/000006546
Abstract
The maternal transfer of antibodies is a vital process that provides newborns with passive immunity against various pathogens. This study delves into the dynamics of antibody transfer in the context of SARS-CoV-2, Respiratory Syncytial Virus (RSV), and Rift Valley fever virus (RVFV). Our results indicate that vaccination against SARS-CoV-2 during pregnancy not only yields a higher quality and quantity of anti-viral antibodies but also facilitates their enhanced transfer to the fetus. Additionally, the SARS-CoV-2 vaccine appears to reduce inflammation in pregnant women, which may further benefit the antibody transfer process. In contrast, maternal RSV infection correlates with a reduced transfer of antibodies, and these antibodies are of lower quality. This reduction may be linked to an increased inflammatory state in mothers, which could impede the antibody transfer and compromise their efficacy. For RVFV, maternal vaccination leads to elevated titers of antibodies, including neutralizing antibodies, suggesting a strong potential for protective maternal and neonatal immunity. These findings highlight the significance of maternal vaccination in improving neonatal outcomes and underscore the need for ongoing research into the optimization of vaccine strategies for pregnant women.
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Details
- Title
- MATERNAL VACCINATIONS PROVIDE ANTI-VIRAL ANTIBODY PROTECTION TO FETUS IN UTERO
- Creators
- Cody Lauritsen
- Contributors
- Bronwyn Gunn (Chair) - Washington State University, Paul G. Allen School for Global Animal HealthMichela Ciccarelli (Committee Member)Anthony Nicola (Committee Member)Anders Omsland (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 115
- Identifiers
- 99901121438001842
- Language
- English
- Resource Type
- Dissertation