Dissertation
MODELING OF NEURAL ACTION POTENTIAL IN THE ELECTRO-DIFFUSION REGIME
Washington State University
Doctor of Philosophy (PhD), Washington State University
01/2021
DOI:
https://doi.org/10.7273/000003342
Handle:
https://hdl.handle.net/2376/124130
Abstract
The dynamic of membrane potential and ionic concentrations control the transfer of transient electrical and chemical signals from one neuron to another by an action potential. In modeling
neurons, it is generally assumed that the diffusion current in the governing equation for action
potential generation, such as the well-known cable model, is too small to be worth taking into
account. The purpose of this study is to confirm that this assumption invalidates the Nernst-Planck equation, which is the basic flow of ions dynamic in computational neuron science.
Moreover, previously completed studies either ignore drift flux or the studies ignore diffusion
flux from the ions’ concentration calculation. Due to those neglect, the understanding of the
differences in the results are unclear. In the first component of the study, and to reflect the
complete dynamics of ions flow inside neuron cells in low stimulus current, the diffusion current
was included in the governing equation for action potential generation in two studies. Also, in
the second component of the study, we compared the results by using the cable model with the
concentration governing equation of ions species including; drift flux only, diffusion flux only,
and the Nernst-Planck equation.
In conclusion, this study confirmed that that the diffusion current in the governing equation for
action potential can be a crucial factor, in determining the initiation of action potential generation
in the dynamic equation of membrane potential. In addition, our model results showed that the
neuron morphology, time duration of the stimulus current, and position of stimulus current at the
axon, can impact the prediction of the membrane potential. Also, the prediction of membrane
potential showed distinguish results of membrane potential when the concentration governing
equation of ions species was including; drift flux only, diffusion flux only, Nernst-Planck
equation. More importantly, this study shows a new concept of research in predicting the action
potential as the rheobase stimulus current is applied to simulate the action potential in an electro-diffusion model. Regarding the results of this study, more research can be done to establish
greater statistical power.
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Details
- Title
- MODELING OF NEURAL ACTION POTENTIAL IN THE ELECTRO-DIFFUSION REGIME
- Creators
- AHMED JASIM HAMZAH
- Contributors
- Prashanta Dutta (Advisor)Alexander Dimitrov (Committee Member)Jin Liu (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Mechanical and Materials Engineering, School of
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 152
- Identifiers
- 99900652103401842
- Language
- English
- Resource Type
- Dissertation