Dissertation
On the development of the Angiotensin IV ligands, Norleual and NLE -Angiotensin IV, as anti-cancer and wound healing agents
Washington State University
Doctor of Philosophy (PhD), Washington State University
08/2008
DOI:
https://doi.org/10.7273/000005844
Abstract
Cancer and defective wound healing continue to be formidable clinical challenges accounting for billions of dollars in health care expenditures annually. Newly emerging treatment modalities for treating these diseases include the design and recombinant production of growth factors to promote wound healing and monoclonal antibodies to inhibit primary and secondary tumor development. These therapies have shown to be effective, but expensive to produce. In this dissertation, we provide an alternative to recombinant technology in the form of peptide agonists and antagonists. These molecules are relatively inexpensive and simple to synthesize with potent affinities for their target sites. In this dissertation, we show that the AT4 antagonist, Norleual, blocks cMet signaling and cellular effects in Madin-Darby Canine Kidney cells, providing further evidence to support its anti-cancer mechanism of action. In addition, we show that an AT4 agonist, Nle1-AngIV, accelerates both normal and impaired wound healing.
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Details
- Title
- On the development of the Angiotensin IV ligands, Norleual and NLE -Angiotensin IV, as anti-cancer and wound healing agents
- Creators
- Patrick David Elias
- Contributors
- Joseph W. Harding (Chair)Jay Wright (Committee Member)Michael Varnum (Committee Member) - Washington State University, Department of Integrative Physiology and NeuroscienceBarabara A Sorg (Committee Member)Raymond Quock (Committee Member) - Washington State University, Department of Psychology
- Awarding Institution
- Washington State University
- Academic Unit
- College of Pharmacy and Pharmaceutical Sciences
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 86
- Identifiers
- 99901055035501842
- Language
- English
- Resource Type
- Dissertation