Dissertation
PRECURSORS OF BIOLOGICALLY RELEVANT REACTIVE SULFUR SPECIES AND THEIR APPLICATIONS
Doctor of Philosophy (PhD), Washington State University
01/2019
Handle:
https://hdl.handle.net/2376/17876
Abstract
Reactive sulfur species (RSS) are a group of sulfur containing molecules playing important regulatory roles in the biological system. Representative RSS include thiols (RSH), hydrogen sulfides (H2S), persulfides (RSSH), hydrogen polysulfides (H2Sn, n>1), polysulfides (RSSnSR, n>1) and S-modified protein cysteine adducts such as S-nitrosothiols (RSNO) and sulfenic acids (RSOH). Many RSS are highly reactive and transient molecules, making their studies difficult. RSS donors or precursors, which are used to specifically produce or deliver RSS, are useful research tools, as well as possible therapeutic agents. To this end, I have developed novel precursors to controllably release RSS. I have studied Ammonium Tetrathiomolybdate as an H2S donor and found it showed H2S-related bioactivities; I have developed 9-fluorenyl disulfides as persulfide precursors for the synthesis of unsymmetrical trisulfides; I have discovered diacyl disulfides can generate H2S2 under amine activation and studied the redox chemistry of H2S2 generated by this method; finally, I have helped the development of OS relay deprotection as a general strategy for designing RSS donors. These precursors serve as important chemical tools for studying chemistry of RSS and exploring their therapeutic potentials.
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Details
- Title
- PRECURSORS OF BIOLOGICALLY RELEVANT REACTIVE SULFUR SPECIES AND THEIR APPLICATIONS
- Creators
- Shi Xu
- Contributors
- Ming Xian (Advisor)Rock Mancini (Committee Member)Cliff Berkman (Committee Member)Hector Aguilar-Carreno (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Department of Chemistry
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 180
- Identifiers
- 99900581501701842
- Language
- English
- Resource Type
- Dissertation