Dissertation
Superoxide production in respiratory electron transport minimization and utilization
Washington State University
Doctor of Philosophy (PhD), Washington State University
12/2008
DOI:
https://doi.org/10.7273/000005848
Abstract
The oxidation of ubiquinol by the cytochrome bc1 complex is usually a tightly controlled process, however there are instances when the reaction is compromised by mutation or other external factors such as inhibitors that leads to superoxide production. The first part of this dissertation compares the electron transfer reactions between when the enzyme is performing efficiently and when superoxide production is taking place. The results of this section suggest that the same rate limiting step governs the two reactions, which allows for the elimination of several models explaining these critical reactions.
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Details
- Title
- Superoxide production in respiratory electron transport minimization and utilization
- Creators
- Isaac Paul Forquer
- Contributors
- David M Kramer (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Molecular Biosciences
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 78
- Identifiers
- 99901055039501842
- Language
- English
- Resource Type
- Dissertation