Dissertation
Synthetic uses of S-Nitrosothiols in Organic Chemistry
Doctor of Philosophy (PhD), Washington State University
01/2017
Handle:
https://hdl.handle.net/2376/12941
Abstract
S-Nitrosothiols have risen to prominence since their identification as an important post-translational modification of cysteine residues.
The full range of chemistry and biological implications of this motif are under exploration.
Direct chemical reactions of S-nitrosothiols should reveal clues into their biological effects, and produce new synthetic tools for the construction of sulfur and nitrogen containing compounds.
Here several explorations into synthetic applications of S-Nitrosothiols are explored.
The relevant background literature is reviewed.
Then a phosphine mediated reductive ligation of aldehydes and S-Nitrosothiols is discussed.
Followed the development of a proline-based phosphine reagent and its reactivity with S-nitrosothiols is explored.
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Details
- Title
- Synthetic uses of S-Nitrosothiols in Organic Chemistry
- Creators
- Tyler Biggs
- Contributors
- Ming Xian (Advisor)Cliff Berkman (Committee Member)Aurora Clark (Committee Member)Jeffrey P. Jones (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Department of Chemistry
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 100
- Identifiers
- 99900581829201842
- Language
- English
- Resource Type
- Dissertation