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Natalie Kallish_Dissertation_2026_Development of reliable DNA circuits
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Dissertation
THE DEVELOPMENT OF RELIABLE DNA CIRCUITS: GATEWAYS TOWARDS A DNA CHEMICAL COMPUTER
Doctor of Philosophy (PhD), Washington State University
2026
Abstract
Molecular programming leverages DNA as a versatile building block for constructing physical structures, designing chemical circuits, and engineering interfaces with materials. DNA-based structures, circuitry, and material interfaces collectively provide a foundation for advancing and developing programmable materials with potential applications spanning medicine, soft robotics, and material science.This dissertation presents progress toward the realization of a DNA-based chemical computer. Specifically, it includes a theoretical framework demonstrating that chemical reaction networks (CRNs) can emulate the fundamental components of analog electronic computers (resistors, capacitors, and inductors). As well as exploring experimental implementation of four-way DNA strand displacement (4wDSD), a reaction mechanism characterized by high specificity and robustness, which are necessary elements for scalable molecular computation. The 4wDSD CRNs investigated include an activation mechanism and a signal amplification system, both of which serve as foundational elements for constructing more complex circuits.
The development of a functional DNA computer will require large-scale circuit integration and reliable interconnectivity between components. The selectivity and low crosstalk of 4wDSD systems position them as a promising platform for enabling such scalable chemical computing architectures.
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Details
- Title
- THE DEVELOPMENT OF RELIABLE DNA CIRCUITS: GATEWAYS TOWARDS A DNA CHEMICAL COMPUTER
- Creators
- Natalie Kallish
- Contributors
- Dominic Scalise (Advisor)Bernard Van Wie (Committee Member)Alla Kostyukova (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Chemical Engineering and Bioengineering
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 76
- Identifiers
- 99901421306301842
- Language
- English
- Resource Type
- Dissertation