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CC BY V4.0, Open Access
Dissertation
THE EVOLUTIONARY SIGNIFICANCE OF RECOMBINATION HOTSPOTS
Washington State University
Doctor of Philosophy (PhD), Washington State University
01/2021
DOI:
https://doi.org/10.7273/000005425
Handle:
https://hdl.handle.net/2376/119091
Abstract
Recombination, or the exchange of genetic material between homologous chromosomes during meiosis, generates genomic variation and can allow selection to act more efficiently. The rate of recombination varies between species, populations, sexes, chromosomes, and along chromosomes. One common form of recombination rate along chromosomes is the concentration of recombination events in small regions know as recombination hotspots. Recombination hotspots reduce the probability that alleles at loci on either side of them will be inherited together, thereby guiding which genetic variants will tend to be inherited together. The location of recombination hotspots also varies between species and populations, as do the features that correlate with them. In most taxa, recombination hotspots tend to be found near functional genomic elements, but in some vertebrates, including humans and mice, the DNA-binding protein PRDM9 directs hotspot location. Here we study the population-level dynamics of recombination hotspots by constructing fine-scale maps of recombination and identifying hotspots for ten populations of the cocoa tree (Theobroma cacao). We also explore the genomic interactions between recombination and meiotic transcription in the presence of PRDM9 by leveraging existing genomic data from lab mice (Mus musculus). Finally, we analyze how the evolutionary history of a population can affect fine-scale estimates of recombination using mathematical and evolutionary models of fluctuating selection at two loci.
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Details
- Title
- THE EVOLUTIONARY SIGNIFICANCE OF RECOMBINATION HOTSPOTS
- Creators
- Enrique Schwarzkopf Kratzer
- Contributors
- Omar E Cornejo (Advisor)Jeremiah W Busch (Committee Member)Richard Gomulkiewicz (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Biological Sciences
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 154
- Identifiers
- 99900592155501842
- Language
- English
- Resource Type
- Dissertation