Dissertation
THE ROLE OF REDOX AND EXTRACELLULAR MATRIX SUBSTRATES IN SLEEP/WAKE REGULATION
Washington State University
Doctor of Philosophy (PhD), Washington State University
01/2022
DOI:
https://doi.org/10.7273/000004544
Handle:
https://hdl.handle.net/2376/125121
Abstract
Sleep insufficiency is a public health epidemic of growing concern. The around-the-clock demands of modern society are associated with cognitive impairment as a result of sleep loss. These impairments adversely impact school performance, the labor market, and public safety. A complicated network of social and environmental factors undermines sleep opportunities in large portions of our population. Until such time when these factors can be remedied, we can improve the efficiency of sleep, itself, if we understand the underlying cellular processes which drive and are driven by sleep. The overall objective of this thesis is to identify and characterize the mechanisms that affect the brain’s capacity to withstand oxidative stress during prolonged wakefulness. This dissertation examines the roles of extracellular matrix components and oxidation-reduction (redox) reaction substrates in mitigating the effects of oxidative stress on sleep/wake cycles and electroencephalographic manifestations of sleep and sleepiness. The chapters enclosed probe the extracellular and intracellular mechanisms which protect the brain from oxidative stress during wakefulness, and ascertain their capacity to support waking electroencephalographic activity associated with cognition and oscillations which determine sleep efficiency. Collectively, these findings produce a model which describes the extracellular and intracellular redox mechanisms which impact cortical manifestations of sleep and sleepiness.
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Details
- Title
- THE ROLE OF REDOX AND EXTRACELLULAR MATRIX SUBSTRATES IN SLEEP/WAKE REGULATION
- Creators
- Priyanka Naga Bushana
- Contributors
- Jonathan P Wisor (Advisor)Barbara A Sorg (Advisor)Christopher J Davis (Committee Member)Marcos G Frank (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Program in Neuroscience
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 219
- Identifiers
- 99900898538501842
- Language
- English
- Resource Type
- Dissertation