Dissertation
The Marine Compound Tartrolon E Targets the Asexual and Early Sexual Stages of Cryptosporidium Parvum
Washington State University
Doctor of Philosophy (PhD), Washington State University
2023
DOI:
https://doi.org/10.7273/000005274
Abstract
Cryptosporidiosis is a diarrheal disease with a recurrent global impact. The only FDA approved treatment against the disease, nitazoxanide, is ineffective on immunocompromised population and not recommended for use on children under 2 years old. In healthy adults, infections with Cryptosporidium parasites can cause life-long digestive syndromes even after resolution of the infection. Characterization of novel compounds that have activity against Cryptosporidium is a critical medical necessity. TrtE is a marine compound that has shown anti-apicomplexan activity. In this dissertation, the effect of trtE on Cryptosporidium life stages is explored. TrtE kills the parasite within an hour of treatment and targets the asexual stage and early sexual stages of Cryptosporidium parasites. Furthermore, preliminary data using Drug Affinity Responsive Target Stability (DARTS) revealed a potential target of trtE in Toxoplasma gondii. These data will serve as a foundation for future studies with trtE in apicomplexan parasites.
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Details
- Title
- The Marine Compound Tartrolon E Targets the Asexual and Early Sexual Stages of Cryptosporidium Parvum
- Creators
- Alexis Gerardo Cotto-Rosario
- Contributors
- Roberta O'Connor (Advisor)Anthony V Nicola (Committee Member)Dana K Shaw (Committee Member)Carlos E Suarez (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Publisher
- Washington State University
- Number of pages
- 63
- Identifiers
- 99901019938501842
- Language
- English
- Resource Type
- Dissertation