Dissertation
UNDERSTANDING THE MOLECULAR DRIVERS OF EMBRYOGENESIS TO ADVANCE ASSISTED REPRODUCTIVE TECHNOLOGIES
Doctor of Philosophy (PhD), Washington State University
2026
Abstract
Embryogenesis describes the transformation of a single-celled fertilized zygote into a complex organism with distinct tissues and organs. This dissertation synthesizes our current understanding of normal embryo development and emerging knowledge of the molecular mechanisms that govern embryogenesis. The understanding of embryogenesis enables the identification of the causes of infertility and drives the advancement of assisted reproductive technologies (ARTs), techniques designed for the therapeutic manipulation of sperm and eggs to treat infertility in vitro. Research outcomes focus on the requirements for two genetic factors with previously unidentified roles in embryogenesis, arrestin domain containing 5 (Arrdc5) and ankyrin repeat domain 49 (Ankrd49). The goal of this dissertation is to gain a better understanding of the contributions of genetic factors to embryonic development to inform the continued development of ARTs. Understanding the genomic factors that regulate embryogenesis will shape how embryos are screened, cultured, and manipulated in vitro.
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Details
- Title
- UNDERSTANDING THE MOLECULAR DRIVERS OF EMBRYOGENESIS TO ADVANCE ASSISTED REPRODUCTIVE TECHNOLOGIES
- Creators
- Julie Park
- Contributors
- Jon M Oatley (Advisor)Miranda L Bernhardt (Committee Member)Michela Ciccarelli (Committee Member)James A MacLean (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Molecular Biosciences
- Theses and Dissertations
- Doctor of Philosophy (PhD), Washington State University
- Number of pages
- 157
- Identifiers
- 99901394104901842
- Language
- English
- Resource Type
- Dissertation