Encyclopedia entry
Peritubular Myoid Cells in Testis
Encyclopedia of Reproduction, pp.42-46
Elsevier Inc, Second Edition
2018
Abstract
Peritubular myoid cells are cells located along the basal surface (outside wall) of the seminiferous tubules. They are responsible for the seminiferous tubules holding their shape and have contractile ability which promotes the transport of immotile sperm. There are notable differences between humans and rodents, with the number of layers of peritubular cells varying and the size of the extracellular matrix differing. Even after sexual maturity peritubular myoid cells continue the process of dividing. For this reason growth regulation is needed even after reaching adulthood. Peritubular cell–Sertoli cell interactions are vital to the testis and are responsible for many of the components produced in the testis. TGF-β (transforming growth factor-beta) is an agent that helps drive the maintenance of spermatogenesis. Peritubular myoid cells have been found to regulate Sertoli cell function. Leydig cell and peritubular myoid cell interactions are required for Sertoli cell development and function, indicating that peritubular myoid cells are vital to testis biology and function.
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Details
- Title
- Peritubular Myoid Cells in Testis
- Creators
- Ryan P. Thompson - Washington State UniversityEric E. Nilsson - Washington State UniversityMichael K. Skinner - Washington State University
- Publication Details
- Encyclopedia of Reproduction, pp.42-46
- Academic Unit
- Biological Sciences, School of
- Publisher
- Elsevier Inc
- Edition
- Second Edition
- Identifiers
- 99901080814901842
- Language
- English
- Resource Type
- Encyclopedia entry