Essay
Mechanisms of Methamphetamine-enhanced learing and memory in the snail lymnaea stagnalis
2009
Handle:
https://hdl.handle.net/2376/2495
Abstract
After these preliminary experiments to test the effect of Meth on learning and memory, we tested how Meth might be enhancing learning and memory. We investigated separately whether sulpilide (a selective dopamine antagonist) and methiothepin (a serotonin antagonist) could block Meth-enhanced learning. Neither drug produced the necessary results to continue testing them. Serotonin and dopantine each initiate a multitude of molecular cascades, so we decided to focus on one component that they both affect: phosphorylation, specifically, protein kinase A (PKA). We were not able to block Meth-enhanced learning through the PKA inhibitor H89, but further experiments with H89 hold promise for detemlining PKA's possible role in Meth-enhanced learning. Taken together, our research suggests that Meth pre-exposure is doing some type of priming activity that is preparing the animal for better learning.
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Details
- Title
- Mechanisms of Methamphetamine-enhanced learing and memory in the snail lymnaea stagnalis
- Creators
- Samuel M. Kammerzell (Author)
- Contributors
- Barbara A. Sorg (Advisor)
- Academic Unit
- Honors Theses (WSU Pullman, Passed with Distinction)
- Identifiers
- 99900590745701842
- Copyright
- http://rightsstatements.org/vocab/InC/1.0/; http://www.ndltd.org/standards/metadata; http://purl.org/eprint/accessRights/OpenAccess; In copyright; Publicly accessible; openAccess
- Language
- English
- Resource Type
- Essay