Essay
The Roles of CG31221, Shn, and Pura During Coxiella burnetii Infections
Autumn 2022
DOI:
https://doi.org/10.7273/000004645
Abstract
To investigate whether pura is helping Coxiella invade the cells, an experiment was run to analyze the amount of Coxiella outside of the cells. This experiment found that the pura gene had no effect on the amount of bacterial concentration outside of the cell. This information, combined with the knowledge that the pura gene does increase bacterial concentration in totality, suggests that pura could be important for Coxiella vacuole formation, since the pura didn’t increase bacterial concentration outside of the cell as we would expect from our previous data.
Finally, the Coxiella bacterial concentration in male and female flies of the same genetic line were analyzed, and showed the female flies have less Coxiella in them than male lines, suggesting that female flies have a stronger immune response to Coxiella.
All of this information can be used to help us gain a better understanding of Coxiella and its relationship to the innate immune system. By learning more about how our Drosophila model organism fights Coxiella, we can learn more about how to fight it in human populations, knowledge that could potentially save lives.
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Details
- Title
- The Roles of CG31221, Shn, and Pura During Coxiella burnetii Infections
- Creators
- Benjamin M. Hollenberg (Author)
- Contributors
- Alan G Goodman (Contributor) - Washington State University, Molecular Biosciences, School of
- Academic Unit
- Honors Theses (WSU Pullman)
- Identifiers
- 99900921940201842
- Resource Type
- Essay