Thesis
99mTc-DTPA renal scintigraphy in cats with experimentally induced acute kidney injury
Washington State University
Master of Science (MS), Washington State University
2018
Handle:
https://hdl.handle.net/2376/103188
Abstract
Renal scintigraphy could be a reliable technique to detect reduced glomerular filtration rate (GFR) induced by nephrotoxins in cats. The objective of this study was to compare the global GFR, estimated by renal scintigraphy, in healthy cats and cats with acute kidney injury, induced by repeated administration of meloxicam. Twelve intact female cats were treated daily with saline [0.1 mL/kg] (n=6) or meloxicam [0.3 mg/kg] (n=6) subcutaneously for up to 26 days. Global GFR was estimated in all cats using 99mtechnetium diethylenetriamine pentaacetic acid (99mTc-DTPA) renal scintigraphy, before treatment and after 23 or 26 daily treatments of saline or meloxicam. Serum creatinine concentration was also evaluated, immediately prior to both scintigraphy studies. After treatment was complete, four cats in the treatment group had serum creatinine concentrations consistent with grade 2 acute kidney injury. Initially, the estimated global GFR ranged from 2.2 to 3.49 mL/min/kg and from 2.16 to 3.09 mL/min/kg in control and treatment group cats, respectively. Following treatment administration, the estimated global GFR ranged from 2.2 to 3.56 mL/min/kg and from 1.9 to 2.56 mL/min/kg in the control and treatment group cats, respectively. The within and between group estimated GFR medians were not different (p >0.05). The estimation of global GFR using 99mTc-DTPA renal scintigraphy is not a reliable technique to detect acute kidney injury, induced by repeated administration of meloxicam.
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Details
- Title
- 99mTc-DTPA renal scintigraphy in cats with experimentally induced acute kidney injury
- Creators
- Maureen Paige Coutu
- Contributors
- Nicolas Villarino (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525372901842
- Language
- English
- Resource Type
- Thesis