Thesis
A randomized, blinded, controlled study comparing methods of topical, epidural morphine application for post hemilaminectory analgesia in dogs
Washington State University
Master of Science (MS), Washington State University
2017
Handle:
https://hdl.handle.net/2376/101308
Abstract
Application of preservative free morphine directly to the spinal cord has been shown to be an effective method of analgesia in dogs and humans undergoing laminectomy procedures. There are various methods of application that have never been directly compared to each other. The aim of this study was to compare different methods of topical morphine application and evaluate a new method utilizing Poloxamer gel which has been shown to have both slow release properties and prevent laminectomy membrane formation. Twenty six dogs completed the study protocol. No statistically significant differences were found between the saline control group, application of morphine directly to the spinal cord, application to the gelfoam over the surgery site and application in the Poloxamer gel. Several dogs in the control group were never scored to be painful and did not receive rescue analgesia during the 24 hour study period. Overall this study demonstrated the limitations of pain assessment in dogs. However, morphine-Poloxamer compounds deserve further investigation as they could be beneficial as an adjunctive analgesic after hemilaminectomy in dogs as well as a method to prevent laminectomy membrane formation.
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Details
- Title
- A randomized, blinded, controlled study comparing methods of topical, epidural morphine application for post hemilaminectory analgesia in dogs
- Creators
- Alexandra Elizabeth Dixon
- Contributors
- Annie Chen-Allen (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525371001842
- Language
- English
- Resource Type
- Thesis