Thesis
Anabolic-androgenic steroid effects on acute & chronic nociception and morphine antinociception
Washington State University
Master of Science (MS), Washington State University
2010
Handle:
https://hdl.handle.net/2376/102357
Abstract
While AAS affected body weight and reproductive organ weights in a mostly expected manner, AAS did not significantly alter acute nociception nor did they significantly attenuate the development of various pain parameters after administration of CFA. Further, morphine antinociception was only modulated by DHT, only on the hotplate test, and in the opposite direction to what was predicted: rather than potentiating morphine antinociception, DHT decreased morphine potency. The findings of this study have produced results that conflict with many past findings of experiments that utilized gonadectomized subjects, implicating a need for further pain studies done in gonadally intact subjects that more accurately model human AAS users.
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Details
- Title
- Anabolic-androgenic steroid effects on acute & chronic nociception and morphine antinociception
- Creators
- Kimberly T. Tsutsui
- Contributors
- Rebecca M. Craft (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Psychology, Department of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; Pullman, Wash. :
- Identifiers
- 99900525039901842
- Language
- English
- Resource Type
- Thesis