Thesis
CLINICAL CHARACTERISTICS AND OUTCOME IN DOGS TREATED WITH TRANSSPHENOIDAL HYPOPHYSECTOMY FOR NON-FUNCTIONAL SELLAR MASSES
Washington State University
Master of Science (MS), Washington State University
01/2022
DOI:
https://doi.org/10.7273/000004502
Handle:
https://hdl.handle.net/2376/125287
Abstract
Objective: To characterize the clinical features, neurological examination findings, diagnostic imaging results, histopathological findings, and outcome following transsphenoidal hypophysectomy (TSH) in dogs with non-functional sellar masses (NFSM).Study design: Multi-institutional retrospective study.
Methods: Medical records of dogs that underwent TSH for a confirmed NFSM were reviewed. Owners were contacted to assess long-term survivors.
Results: The most common clinical sign at presentation was mentation change (12/15). The average pituitary to brain ratio (P/B ratio) was 1.05 (0.6-1.4), and most dogs had a tumor imaging classification of 5B (8/14). The most common tumor type was pituitary adenoma (11/15). Peri-operative mortality was moderate (5/15), specifically when tumors were not adenomas. The median survival for all dogs was 232 days (0-1658), and when dogs that did not survive to discharge were excluded, the median survival time was 708 days. Seven out of 10 owners of long-term survivors responded, reporting an excellent (6/7) to good (1/7) outcome. Most dogs that survived the peri-operative period received post-operative adjunctive therapy (7/10).
Conclusion: Dogs with NFSM commonly presented with large tumors causing mass effect leading to mentation changes. Dogs that underwent TSH for a NFSM causing clinical signs of mass effect and survived to discharge had good to excellent outcomes as reported by owners.
Clinical significance: TSH can be considered for the treatment of NFSM causing clinical signs of mass effect in dogs. Successful long-term outcomes are possible. Adjunctive therapy may improve survival when done in conjunction with surgery.
Metrics
2 File views/ downloads
17 Record Views
Details
- Title
- CLINICAL CHARACTERISTICS AND OUTCOME IN DOGS TREATED WITH TRANSSPHENOIDAL HYPOPHYSECTOMY FOR NON-FUNCTIONAL SELLAR MASSES
- Creators
- Brittany Renee Hyde
- Contributors
- Boel Fransson (Advisor)Linda G Martin (Committee Member)Tina J Owen (Committee Member)Macarena Sanz (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Number of pages
- 30
- Identifiers
- 99900882330901842
- Language
- English
- Resource Type
- Thesis