Thesis
Cannabidiol-[THC symbol}-Tetrahydrocannabinol interactions on antinociception in male vs. female rats
Washington State University
Master of Science (MS), Washington State University
2016
Handle:
https://hdl.handle.net/2376/101529
Abstract
The purpose of this study was to compare the interactions between two primary constituents of marijuana, cannabidiol (CBD) and 9 -tetrahydrocannabinol (THC), on tests of acute pain and locomotor activity in male vs. female rats. Experiment 1 tested the hypothesis that CBD enhances THC's antinociceptive and hypolocomotive effects. A single dose of CBD (10 or 30 mg/kg i.p.) was administered 15 min before a single dose of THC (1.8-10 mg/kg i.p.), and rats were tested for antinociception (warm water tail withdrawal and paw pressure tests) and locomotor activity 15-360 min post-THC injection. Experiment 2 tested the hypothesis that a long CBD pretreatment time will enhance THC's effects more than a short pretreatment time. CBD 30 mg/kg was injected 13 hr or 15 min before THC 1.8 mg/kg, and rats were tested 30-480 min post-THC injection. In Experiment 1, THC produced greater antinociception in females than males, while CBD alone produced no effect on either nociceptive test. CBD slightly enhanced THC-induced paw pressure antinociception at 240-360 min post-THC injection. CBD alone increased locomotor activity at 360 min, while enhancing THC-induced hypolocomotion at 240-360 min post-THC injection, at lower THC doses. In Experiment 2, CBD pretreatment time did not significantly affect CBD-THC interactions. The present results suggest that CBD can enhance THC's antinociceptive and hypolocomotive effects, primarily by prolonging THC's duration of action. CBD-THC interactions may be dose- and time-dependent, but do not appear to be sex-dependent. It is unclear at present whether the interval between CBD and THC administration influences the drug interaction.
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Details
- Title
- Cannabidiol-[THC symbol}-Tetrahydrocannabinol interactions on antinociception in male vs. female rats
- Creators
- Stevie Christine Britch
- Contributors
- Rebecca M. Craft (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Educational Leadership, Sport Studies, and Educational/Counseling Psychology, Department of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525092501842
- Language
- English
- Resource Type
- Thesis