Thesis
Characterization of high-Reynolds deterministic lateral displacement in terms of angle of attack of the airfoil shaped pillar
Washington State University
Master of Science (MS), Washington State University
05/2020
DOI:
https://doi.org/10.7273/000004050
Handle:
https://hdl.handle.net/2376/125113
Abstract
Deterministic lateral displacement (DLD) is a microfluidic technique for size based label-free separation of particles or cells in continuous flow with a great potential for biological and clinical applications. Various applications include circulating tumor cell (CTC) separation, point-of-care diagnosis demand high-throughput operation of DLD devices for rapid processing of biosample. This growing demand is making it necessary to investigate DLD behavior at moderate to high Reynolds number (Re) regimes. Recently, it has been shown that symmetric airfoil shaped pillars with neutral angle-of-attack (AoA) can be used for high-throughput design of DLD devices due to their mitigation of vortex effects and preservation of flow symmetry under high Re conditions. While high-Re operation with symmetric airfoil shaped pillars has been established, the effect of AoAs on the DLD performance has not been investigated. In this thesis, the characterization of the airfoil DLD device was performed in term of AoAs. The transport behavior of microparticles having sizes ranging from 10 [mu]m to 25 [mu]m has been observed and analyzed with various AoAs in realistic high-Re regime. Furthermore, we have modeled the flow fields and anisotropy in a representative airfoil pillar array, for both positive and negative AoA configurations. Unlike the conventional DLD device, lateral displacement has been suppressed with +5º and +15º AoA configurations regardless of particle sizes. On the other hand, stronger lateral displacement has been seen with -5º and -15º AoAs. Also, the suppression of lateral displacement in positive AoA devices and higher tendency of lateral displacement in negative AoA devices increases with the magnitude of the AoAs. This can be attributed to growing flow anisotropy as Re climbs, and significant expansion or compression of streamlines between airfoils with AoA. The findings in this study can be utilized for the design and optimization of airfoil DLD microfluidic devices with various AoAs.
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Details
- Title
- Characterization of high-Reynolds deterministic lateral displacement in terms of angle of attack of the airfoil shaped pillar
- Creators
- Kawkab Ahasan
- Contributors
- Jong Hoon Kim (Advisor) - Washington State University, School of Engineering and Computer Science (VANC)
- Awarding Institution
- Washington State University
- Academic Unit
- School of Engineering and Computer Science (VANC)
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Identifiers
- 99900890792901842
- Language
- English
- Resource Type
- Thesis