Thesis
Cryoprecipitate transfusion in 21 dogs for prevention and/or treatment of hemorrhage: A retrospective study (2009-2023)
Washington State University
Master of Science (MS), Washington State University
2023
DOI:
https://doi.org/10.7273/000006288
Abstract
The objective of this study was to assess the response to homologous cryoprecipitate transfusion in dogs with hemostatic disorders and/or hemorrhage including transfusion reactions. The medical record of dogs receiving a cryoprecipitate transfusion at the Washington State University Veterinary Teaching Hospital between July 2009 and July 2023 were reviewed. Twenty-one client-owned dogs with hemostatic disorders and/or hemorrhage were included in the study. Sixteen dogs had von Willebrand disease (one also had factor XI deficiency); three dogs had hemophilia A; two dogs had normal concentration of von Willebrand factor and were not diagnosed with any hemostatic disorder. Sixteen dogs also received other blood products and/or hemostatic medications. Twenty-two cryoprecipitate transfusions were administered to 16 dogs before, during or after surgery; Sixteen of those 22 transfusions were given to 14 dogs without evidence of hemorrhage but with history of bleeding disorders and/or previous hemorrhage with the aim of preventing hemorrhage. Eight transfusions were given to six dogs to control hemorrhage not associated with surgery. Sixteen dogs (18 transfusions) received cryoprecipitate prepared in-house. Five dogs (12 transfusions) received a commercial lyophilized cryoprecipitate. No dog developed any serious adverse reactions to cryoprecipitate transfusion. All dogs were discharged from the hospital (median, 2 days after cryoprecipitate transfusion [range, 1-25 days]). The benefits of canine cryoprecipitate transfusion could not be well documented in this study because of its retrospective nature, and the concurrent administration of other blood products and/or hemostatic medications to 16 dogs. Homologous cryoprecipitate transfusion appeared to be safe and effective for prevention and/or treatment of hemorrhage in dogs, but additional studies to assess safety and efficacy are warranted.
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Details
- Title
- Cryoprecipitate transfusion in 21 dogs for prevention and/or treatment of hemorrhage
- Creators
- Wui Yung Eunice Lam
- Contributors
- Linda Gail Martin (Advisor)Katherine J. Wardrop (Committee Member)Jillian M. Haines (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- College of Veterinary Medicine
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Number of pages
- 35
- Identifiers
- 99901086432701842
- Language
- English
- Resource Type
- Thesis