Thesis
Design enhancements for high-flow high-resolution stand-alone ion mobility spectrometry
Washington State University
Master of Science (MS), Washington State University
05/2020
DOI:
https://doi.org/10.7273/000004293
Handle:
https://hdl.handle.net/2376/124616
Abstract
Since its inception into the analytical community thirty years ago, ion mobility spectrometry (IMS) has been considered a simple and useful, yet low resolution technique. The stigma of low resolving power on IMS has made it somewhat unattractive to large-scale commercialization and thus has limited its utility in mainstream analytical chemistry. In this work I have focused on the effect of applied drift field inhomogeneity on the resolving power of IMS. It is shown here that changes in drift-ring size and the distance established between drift rings can have a significant effect on IMS resolving power. It is also shown that through the implementation of a novel aperture design, that IMS resolving power can be selected: from very low resolving power for the highest possible sensitivity, to high resolving power for separation of closely spaced peaks. These designs can be applied to all existing and future ion mobility spectrometers to more than double the typical IMS resolution without the use of mass spectrometry.
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Details
- Title
- Design enhancements for high-flow high-resolution stand-alone ion mobility spectrometry
- Creators
- Pete Tornatore
- Contributors
- Herbert H. Hill Jr. (Advisor) - Washington State University, Chemistry, Department of
- Awarding Institution
- Washington State University
- Academic Unit
- Chemistry, Department of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Identifiers
- 99900896400901842
- Language
- English
- Resource Type
- Thesis