Thesis
Dose-rate effects of ¹³⁷Cs on survival time in the beagle dog
Washington State University
Master of Science (MS), Washington State University
2011
Handle:
https://hdl.handle.net/2376/100227
Abstract
Animal models have been studied to predict probable effects of radiation on humans. Studies done from the late 1950s through the 1980s used the Beagle dog as an animal model for radiation effects. Laboratories from around the world irradiated many Beagle dogs with various radioactive isotopes. Studies were performed at the Inhalation Toxicology Research Institute (ITRI) and at Argonne National Laboratory (ANL) using cesium chloride to irradiate a total of 117 Beagle dogs. The exposure to the cesium chloride was through an acute injection and spanned a range of initial dose rates of 0.2 Gy/day to 1.0 Gy/day with continuous internal exposure to the radionuclide in accordance with the retention of cesium. Data and reports on the Beagle dogs irradiated with the isotope 137Cs were collected and analyzed for dose rate effects. The purpose of this study was to establish dose-rate related effects of 137Cs exposure by determining if a threshold of exposure to the radionuclide exists for any adverse health effect. Survival analyses for all-cause and cause-specific mortality following irradiation have been conducted. By complementing research on 137Cs metabolism in man, the results from this study may help develop a better understanding of the potential biological effects of internal exposure of 137Cs in a large animal model.
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Details
- Title
- Dose-rate effects of ¹³⁷Cs on survival time in the beagle dog
- Creators
- Erika June Peterson
- Contributors
- Allan S. Felsot (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Environment, School of the (CAHNRS)
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; Pullman, Wash. :
- Identifiers
- 99900525300401842
- Language
- English
- Resource Type
- Thesis