Thesis
Effect of viscosity on high throughput deterministic lateral displacement (DLD) devices
Washington State University
Master of Science (MS), Washington State University
05/2021
DOI:
https://doi.org/10.7273/000004285
Handle:
https://hdl.handle.net/2376/125011
Abstract
Deterministic Lateral Displacement (DLD) is a microfluidic particle separation technique which continues to show promise as a great potential for biosample preparation. DLD shifts particles that have a diameter larger than or equal to the critical diameter (Dc) laterally, while particles smaller than the Dc travel straight through the device showing no lateral shift. This is an effective concentration method for use in biosensing because the sample preparation process is performed on a small microfluidic chip, can be integrated into a lab on a chip (LOC), and often does not require large scale external equipment. As biosensors continue to become smaller and more portable for use in Point of Care (POC) diagnostic testing, bio-sample preparation needs to become more portable or integrate with biosensors to ensure that the testing process is not bottlenecked by the need for large scale sample preparation equipment. DLD can fill this role by separating particles based off physical properties such as size and density and have even shown the ability for high throughput sampling and separation of multiple Dc’s within a single device. In this research, we test the performance of high-throughput DLD to examine Dc at a range of Reynolds (Re) numbers with alterations to fluid viscosity to resemble that of biological fluids. Previous studies have found that as Re is increased, Dc decreases. It was found in this study that alterations to the viscosity of fluid do not alter this trend, and as the associated Re of the flow increases, the Dc decreases as previously shown. At matching Re, increases to the viscosity result in an increase of pressure within DLD devices. In this study, particles began to shift at a Reynolds number of approximately 20 and 12, for a neutral and negative Angle of Attack (AoA) respectively. This shift occurred regardless of viscosity. However, the smaller particle size tested of 15[mu]m did not enter a full displacement mode in the neutral device. It was found that a negative AoA used with an airfoil DLD pillar design provided the best shift to negate pressure increases which can cause DLD devices to fail.
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Details
- Title
- Effect of viscosity on high throughput deterministic lateral displacement (DLD) devices
- Creators
- Brian Lewis Senf
- Contributors
- Jong Hoon Kim (Advisor) - Washington State University, Engineering and Computer Science (VANC), School of
- Awarding Institution
- Washington State University
- Academic Unit
- Engineering and Computer Science (VANC), School of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Identifiers
- 99900896412201842
- Language
- English
- Resource Type
- Thesis