Thesis
Effects of MK-801 on opioid antinociception: An examination of morphine, U50, 488H and SNC80 in male and female rats
Washington State University
Master of Science (MS), Washington State University
2003
Handle:
https://hdl.handle.net/2376/155
Abstract
Age-matched pairs of male and female Sprague-Dawley rats were given mu-, kappa-, and delta-opioid agonists (morphine, U50,488h, and SNC80, respectively) in combination with NMDA antagonist MK801 and time course data were obtained. Antinociceptive effects were measured on the hotplate and tail withdrawal assays, but results were significant only on the hotplate assay, suggesting a supraspinal mechanism for NMDA-opioid interactions. While MK801 had no significant effect on U50,488h and SNC80 antinociception, it both antagonized and potentiated morphine antinociception. These results underscore the unpredictable nature of the effects of NMDA antagonists on morphine effects and suggest new areas for future research.
Metrics
3 File views/ downloads
7 Record Views
Details
- Title
- Effects of MK-801 on opioid antinociception
- Creators
- Joanna Michelle Mann-Jones
- Contributors
- Craig D. Parks (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Psychology, Department of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; Pullman, Wash. :
- Identifiers
- 99900525072801842
- Language
- English
- Resource Type
- Thesis