Thesis
Evaluating the Benefits of Cannabidiol Following Surgical Intervention for Intervertebral Disc Herniation in Dogs: A Randomized Double Blinded Controlled Study
Washington State University
Master of Science (MS), Washington State University
2021
DOI:
https://doi.org/10.7273/000005536
Abstract
The use of cannabidiol (CBD) in veterinary medicine has recently gained research interest and shown promise in the treatment of pain in canines. The aim of this study was to assess the effectiveness of CBD oil for analgesia with gabapentin as part of an oral treatment regimen in post- surgical intervention in dogs following acute Hansen Type 1 intervertebral disk extrusion. In this randomized, double blinded, prospective, clinical trial, dogs were randomized based on a temporal randomized block design into one of two treatment groups (Group 1: oral gabapentin only and CBD treatment, Group 2: oral gabapentin and placebo). At the end of surgery, all patients were given a dose of injectable methadone and were immediately started on the oral treatments based off their treatment group. Patients were pain scored using the Modified Glasgow Composite Scale every 2 hours for the first 24 hours following surgery. For the next 24 hours, patients were pain scored every 4 hours until the completion of the study at 48 hours. Rescue analgesia with parental methadone was given to any patients with a pain score of > 5/20. Average pain scores over 48-hours, need for rescue analgesia and total doses of rescue analgesia over the 48-hour period were recorded. Twenty-one dogs completed the study. No statistical differences were found between the treatment groups. There was a statistically significant difference between need for analgesia rescue and intra-operative glucocorticoid use, with dogs receiving intraoperative glucocorticoid being less likely to require post-operative opioids in the immediate post-operative period. While this study failed to show a statistical difference between CBD oil and placebo treatments, this study demonstrated the safety of CBD oil and gabapentin in post-operative spinal patients lacking concurrent illness. This study also highlighted the importance and challenges of conducting a clinical trial and controlling for additional treatments, such as glucocorticoid use. Further investigation, with increased case numbers, of CBD as an adjunctive analgesic and neuroprotectant following spinal surgery in dogs is warranted.
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Details
- Title
- Evaluating the Benefits of Cannabidiol Following Surgical Intervention for Intervertebral Disc Herniation in Dogs
- Creators
- Hilary Lorraine Wright
- Contributors
- Annie Chen-Allen (Advisor)Linda Martin (Committee Member)Tamara Grubb (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- College of Veterinary Medicine
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Number of pages
- 35
- Identifiers
- 99901051427101842
- Language
- English
- Resource Type
- Thesis