Thesis
Evaluation of a resorbable self-locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model
Washington State University
Master of Science (MS), Washington State University
2018
Handle:
https://hdl.handle.net/2376/100285
Abstract
Objective: To compare the airway leak pressure of a resorbable ligation device (LigaTie) to thoracoabdominal (TA) staples for sealing peripheral lung biopsy sites. Study Design: Ex vivo experimental study. Animals: Four caprine cadavers. Methods: Twelve lung lobes were harvested from 4 goats immediately after euthanasia. Each lobe was inflated to 20 cmH2O to test for leaks prior to biopsy. Pressure was then maintained at 10 cmH2O. Biopsy samples were performed 3 cm from the periphery using either a resorbable ligation device or TA stapler (n = 6 per group). Following biopsy, inflation pressure was slowly increased to a maximum of 40 cmH2O while the lungs were submerged in water. The pressure at which bubbles were first seen was recorded as the airway leak pressure. The length, width, volume, and weight were recorded for each biopsy sample. Results: Five of 6 LigaTie biopsy sites sustained the maximum pressure of 40 cmH2O without leaking. One site leaked at 24 cmH2O. The TA stapled sites sustained airway pressure to median 25.5 cmH2O (IQR 23.5 - 26 cmH2O) and none of them reached the maximum pressure (p = 0.015). There were no differences in biopsy length, volume, or weight between groups. Conclusions and Clinical Relevance: The LigaTie biopsy sites withstood significantly higher airway pressure without leaking compared to TA stapled biopsy sites. This novel device may be an effective method for sealing peripheral lung biopsy sites, but clinical investigation is required.
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Details
- Title
- Evaluation of a resorbable self-locking ligation device for performing peripheral lung biopsies in a caprine cadaveric model
- Creators
- Adam Mark Nylund
- Contributors
- Boel A. Fransson (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525071001842
- Language
- English
- Resource Type
- Thesis