Thesis
HOUSEHOLD SOCIO-ENVIRONMENT AND INFANT FECAL MICROBIOME
Washington State University
Master of Arts (MA), Washington State University
05/2024
DOI:
https://doi.org/10.7273/000006932
Abstract
The “old friends” hypothesis suggests that exposure to a diverse range of co-evolved microbes during early life can regulate the immune system and reduce the risk of allergies. Previous research has shown that household factors are associated with the diversity and composition of the infant gastrointestinal microbiome (IGM). However, there is still limited data on different socio-environmental factors within household that may be associated with the development and composition of the IGM. The fecal microbiome (IFM) is used as an alternative to denote the gastrointestinal microbiome, a common tradition in microbiome literature. Here, we investigate potential relationships between household socio-environmental factors and infant fecal microbiome (IFM) composition and alpha diversity. We analyzed fecal samples from 48 healthy, exclusively breastfed infants from eastern Washington and northwest Idaho. The V1-V3 region of the bacterial 16S rRNA gene was sequenced to describe and analyze the role of household socio-environmental factors on the IFM. Household socio-environmental factors were reported by mothers of infants via survey and through naturalistic observations. Results showed that the household socio-environmental factors in our study were related to the composition of IFM but not the diversity of the IFM.
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Details
- Title
- HOUSEHOLD SOCIO-ENVIRONMENT AND INFANT FECAL MICROBIOME
- Creators
- Maryam Edrisi
- Contributors
- Aaron Blackwell (Chair)Courtney L. Meehan (Committee Member)Edward H. Hagen (Committee Member)Elizabeth A. Holdsworth (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Department of Anthropology
- Theses and Dissertations
- Master of Arts (MA), Washington State University
- Publisher
- Washington State University
- Number of pages
- 47
- Identifiers
- 99901125939901842
- Language
- English
- Resource Type
- Thesis