Methamphetamine, commonly referred to as meth, is the third most frequently abused drug in the United States. It has been directly linked to memory loss, cardiovascular disease, malnutrition, psychotic behavior, and increased risk for HIV and hepatitis. Much has been documented concerning meth's impact on communities, hospitals, emergency services and drug recovery services; very little has been written about the impact this drug has on the primary provider's practice. The purpose of this article is to assist the primary care provider gain understanding of meth's appeal across socioeconomic and geographic boundaries. It also provides a framework for early identification of those at risk and offers insight into health concerns and treatment issues that affect this population.