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CCBY-NCSA_V3.0_US, Open Access
Thesis
Monoclonal Antibodies Infusion Reactions: Etiology, Prediction and Management by Nurse Practitioners
Washington State University
Master of Nursing (MN), Washington State University
05/2012
Handle:
https://hdl.handle.net/2376/4222
Abstract
Monoclonal antibodies have an increased risk of infusion reaction. Factors in the etiology of infusion reactions include percentage of mouse protein; immune response and cytokine release. Reactions typically occur with the initial infusion and in the presence higher tumor burdens. Predictive factors of infusion reactions include prior first infusions, increased amounts of lymphocytes, geographical region and rapid infusions. Management of reactions includes consideration of a test dose, premedication, supportive care and treatment alternatives of fully humanized monoclonal antibodies. Additional management options include desensitization protocols, as well as standing orders and crash cart availability. To improve patient safety, an emphasis is needed on staff education and the development of a process to evaluate and identify patients at risk. Standardized clinical pathways, policies and procedures need to be well rehearsed by staff to reduce negative consequences of infusion reactions. More research is needed on the identification of risk factors, as well as a clearer understanding of the mechanism of a monoclonal antibody infusion reaction. Monetary implications and hospitalizations are important to further determine the direct cost of infusion reactions of monoclonal antibodies.
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Details
- Title
- Monoclonal Antibodies Infusion Reactions: Etiology, Prediction and Management by Nurse Practitioners
- Creators
- Lynette V. Marshall
- Contributors
- Melvin Haberman (Advisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Research Projects, College of Nursing
- Theses and Dissertations
- Master of Nursing (MN), Washington State University
- Publisher
- Washington State University; Spokane, Washington
- Identifiers
- 99900590725301842
- Copyright
- http://creativecommons.org/licenses/by-nc-sa/3.0/us; Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States (CC BY-NC-SA 3.0 US)
- Language
- English
- Resource Type
- Thesis