The syndrome of Type 1 diabetes mellitus includes abnormal blood glucose metabolism and is associated with development of retinopathy, nephropathy and neuropathy. Type 1 diabetes is an autoimmune disease that destroys the beta cells in the islet of Langerhans in the pancreas. It is a catabolic disorder in which circulating insulin is absent and external replacement is required. The DCCT Research Group (1993) proved the value of a rigid schedule of insulin injections to reduce the development of complications. Pancreas islet cell transplantation and whole-organ pancreas transplant are surgical options that may cure Type 1 diabetes. This paper reviews the mechanism of end organ damage caused by the hyperglycemia of Type 1 diabetes, current medical and surgical therapy and describes patient eligibility criteria for transplant for use by the primary care provider.
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Details
Title
Pancreas Transplant: An Option For Treatment of Insulin Dependent Diabetes Mellitus
Creators
Kimberley Everett Koon
Contributors
Lorna Schumann (Advisor)
Awarding Institution
Washington State University
Academic Unit
Research Projects, College of Nursing
Theses and Dissertations
Master of Nursing (MN), Washington State University
Publisher
Washington State University; Spokane, Washington
Identifiers
99900590734101842
Copyright
http://creativecommons.org/licenses/by-nc-sa/3.0/us; Creative Commons Attribution-NonCommercial-ShareAlike 3.0 United States (CC BY-NC-SA 3.0 US)