Thesis
Postoperative clinical gastro esophageal reflux after premedication with metoclopramide and maropitant in 93 dogs
Washington State University
Master of Science (MS), Washington State University
2018
Handle:
https://hdl.handle.net/2376/102423
Abstract
Objective: To investigate the prophylactic effects of pre-operative maropitant and metoclopramide administration on postoperative clinical gastroesophageal reflux (GER), and to identify risk factors for postoperative GER. We hypothesized that the incidence of postoperative clinical GER will be reduced with prophylactic therapy using metoclopramide and maropitant. Design: Prospective randomized controlled clinical study of client-owned dogs. Procedure: Dogs were randomly assigned to receive either no intervention drugs (control group) or a combination of maropitant (1mg/kg Subcutaneous) and metoclopramide (2mg/kg/day continuous rate infusion)(intervention group) prior to surgery. Dogs were subsequently recovered and monitored by the intensive care unit. Results: Of 93 dogs, 14% developed postoperative clinical GER. No significant difference in postoperative clinical GER was noted between groups. Univariate regression analysis identified differences in clinical GER associated with a recent history of vomiting or regurgitation (P=0.0326), gastrointestinal surgery (P= 0.0005), skin and reconstruction surgery (P=0.0235), overweight body condition (P=0.0119), emergency surgery (P=0.0386) and for each hour a patient remained inappetent postoperatively (P= 0.0002). Multivariate regression identified male dogs (odds ratio OR 9.2), overweight body condition (OR 12.3) gastrointestinal surgery (OR 30.5), and the requirement for postoperative dexmedetomidine CRI (OR, 9.6) as risk factors. Conclusions and Clinical Relevance: Prophylactic administration of metoclopramide and maropitant does not reduce clinical GER incidence in the postoperative period. Overweight, male dogs undergoing gastrointestinal surgery that require postoperative dexmedetomidine CRI sedation have increased risk for developing postoperative clinical GER.
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Details
- Title
- Postoperative clinical gastro esophageal reflux after premedication with metoclopramide and maropitant in 93 dogs
- Creators
- Ciaran Jones
- Contributors
- Boel A. Fransson (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525137301842
- Language
- English
- Resource Type
- Thesis