Thesis
RETROSPECTIVE EVALUATION OF INDICATIONS, TRANSFUSION PROTOCOLS AND ACUTE TRANSFUSION REACTIONS ASSOCIATED WITH THE ADMINISTRATION OF LYOPHILIZED CANINE ALBUMIN: 53 CASES (2009 - 2020)
Washington State University
Master of Science (MS), Washington State University
01/2022
DOI:
https://doi.org/10.7273/000004563
Handle:
https://hdl.handle.net/2376/124925
Abstract
The objectives of the present study are to describe the administration of lyophilized canine albumin (LCA) and determine the increase in serum albumin concentrations post LCA transfusion. To describe the incidence and types of acute transfusion reactions (TRs), and associated outcome in dogs presented to the Washington State university Veterinary Teaching Hospital. It is a retrospective and descriptive study from 2009 to 2020. Animals included 53 client owned dogs. Dogs were included in the study if they received a LCA transfusion and had vital sign monitoring recorded for at least for 4 hours after starting the LCA transfusion. The 53 dogs available for study inclusion received 64 LCA transfusions. Signalment; underlying disease; indications for LCA transfusion; pre and post transfusion serum albumin concentration; volume, concentration and dose of LCA; duration of transfusion; administration of other blood products or synthetic colloids; occurrence, timing and type of TR; length of hospitalization; and outcome were recorded. Serum albumin concentrations increased post LCA transfusion with a median dose of 0.56 g/kg and a median post transfusion serum albumin increase of 3 g/L (0.3g/dL) (P = 0.008). Transfusion reactions occurred in 13 of 64 (20.3%) transfusion events. Volume per kg, dose (g/kg), concentration, duration of transfusion and additional administration of synthetic colloids were not associated with TRs. Three (23%) TRs were classified as Febrile Non-Hemolytic Transfusion Reaction, 5 (38.5%) as Transfusion Associated Dyspnea (development of respiratory distress and limited diagnostics) and 5 (38.5%) had clinical signs that could not be defined by one TR category. Six (46.1%) of 13 events were non-severe, 5 (38.5%) severe, and 2 (15.4%) life-threatening. Administration of LCA can be used to increase serum albumin concentrations, although the clinical implications of this increase are unknown. Acute TRs associated with LCA are relatively frequent and can be life-threatening; careful monitoring is vital.
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Details
- Title
- RETROSPECTIVE EVALUATION OF INDICATIONS, TRANSFUSION PROTOCOLS AND ACUTE TRANSFUSION REACTIONS ASSOCIATED WITH THE ADMINISTRATION OF LYOPHILIZED CANINE ALBUMIN: 53 CASES (2009 - 2020)
- Creators
- Emilia Terradas Crespo
- Contributors
- Linda G. Martin (Advisor)Boel A. Fransson (Committee Member)Ashley L. Hanna (Committee Member)Matthew S. Mickas (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- Veterinary Medicine, College of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Number of pages
- 52
- Identifiers
- OCLC#: 1370912025; 99900898640301842
- Language
- English
- Resource Type
- Thesis