Thesis
Relationships between weight, HOMA IR, leptin, adiponectin and interleukin-6, before and after a calorie restricted diet intervention, and in a 6-8 month post diet period, in overweight and obese individuals at risk for type 2 diabetes
Washington State University
Master of Nursing (MN), Washington State University
2008
Handle:
https://hdl.handle.net/2376/101171
Abstract
Obesity is rapidly becoming a worldwide health problem with profound effects on health care costs and individual health. The economic cost of obesity reaches billions of dollars yearly in the United States and continues to rise. Understanding the role of adipose tissue as an endocrine organ and the underlying relationships and interactions of adipose derived cytokines in insulin resistance, type 2 diabetes and the metabolic syndrome is the subject of ongoing research. Serum measurements of cytokines and insulin sensitivity have been noted to change in weight loss induced by calorie restriction. The purpose of this repeated measures design study was to evaluate the effects of a 28 day calorie restricted diet intervention on weight, serum measures of insulin sensitivity (HOMA IR), and the serum cytokines, leptin, adiponectin and interleukin-6 (IL-6). Data were collected at baseline T1, at the end of a calorie restricted diet intervention T2, and in a six to eight month post diet period T3, in a group of overweight or obese individuals (BMI ≥ 26 kg/m²) at risk for type 2 diabetes. Nine subjects, out of the larger parent pilot study (n = 20), provided data for each of the three time comparisons. Serum measures of leptin, adiponectin and IL-6 were measured using ELISA analysis. Significant decreases in T1 to T2 comparisons were found for weight, leptin, HOMA IR and adiponectin. IL-6 decreased but the change did not reach statistical significance. Nearly all the subjects regained weight in the post diet period, and serum levels of HOMA IR and the cytokines returned to baseline. At baseline, adiponectin and weight, and adiponectin and HOMA IR, demonstrated significant negative correlations. Change scores for the T1 to T2 time period were significantly correlated for adiponectin and weight. No significant change scores correlations were noted for the T2 to T3 period. Results of this study suggest that in a small cohort of individuals at risk for developing diabetes, short term calorie restriction achieved significant weight loss and changes in HOMA IR and some cytokines, but the changes were not sustained. Subjects in this study, for the most part, regained weight and HOMA IR and measured cytokines returned to baseline. Therefore, short-term calorie restricted dieting cannot be recommended as a strategy for improving risk factors for developing type 2 diabetes in this population.
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Details
- Title
- Relationships between weight, HOMA IR, leptin, adiponectin and interleukin-6, before and after a calorie restricted diet intervention, and in a 6-8 month post diet period, in overweight and obese individuals at risk for type 2 diabetes
- Creators
- Robert Bryan Netjes
- Contributors
- Jacquelyn L. Banasik (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Nursing, College of
- Theses and Dissertations
- Master of Nursing (MN), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525040101842
- Language
- English
- Resource Type
- Thesis