Juvenile Ossifying Fibroma (JOF) represents a disfiguring disease of humans and animals and has been reported to preferentially affect the rostral mandible of young horses. Currently, the inciting cause of JOF remains to be elucidated. However, previous oral trauma has been identified historically in several cases presented in the literature and anecdotally by attending clinicians. Oral trauma and the subsequent second intention wound healing’s effect on the development of JOF was investigated prospectively over eight weeks utilizing four weaning aged Thoroughbred Cross fillies. Histopathologic evaluation of the healing rostral mandibular incisive bone wounds revealed tissue architecture consistent with JOF in one out of four fillies (25%). These findings support oral trauma as one of the inciting causes of the condition currently characterized as JOF and offer a model for further investigation into JOF and other fibro-osseous conditions of the rostral mandible in juvenile horses.
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Title
SECOND INTENTION WOUND HEALING EFFECTS ON THE DEVELOPMENT OF EQUINE JUVENILE OSSIFYING FIBROMA
Creators
Nicholas P Hall
Contributors
Claude A. Ragle (Advisor)
Kelly D. Farnsworth (Committee Member)
Boel A. Fransson (Committee Member)
Awarding Institution
Washington State University
Academic Unit
College of Veterinary Medicine
Theses and Dissertations
Master of Science (MS), Washington State University