Thesis
THE EFFECT OF FOLLOW UP TOCERANIB PHOSPHATE ON FELINE ORAL SQUAMOUS CELL CARCINOMAS TREATED WITH HYPERFRACTIONATED RADIATION AND CARBOPLATIN
Washington State University
Master of Science (MS), Washington State University
07/2024
DOI:
https://doi.org/10.7273/000007086
Abstract
Oral squamous cell carcinoma is the most common oral tumor in cats but treatment options that provide long term tumor control are limited. Radiation therapy is a reported treatment option, but local tumor control is still difficult to obtain, and additional treatment options are needed. Toceranib phosphate recently emerged as having biologic activity against feline oral squamous cell carcinoma but the mechanism of benefit is unknown. This non-blinded retrospective single institutional study included all patients between 2011 to 2023 that underwent accelerated radiation therapy with concurrent carboplatin as previously described with the exception of one additional dose of radiation, and once the early side effects abated, toceranib phosphate was initiated. The median survival time (MST) and progression free interval (PFI) were assessed for the cats that received toceranib and was compared to the cats that received the same radiation protocol within the same time period that did not receive toceranib.
Overall, 47 cats fit the criteria for all cats irradiated in the time period and 15 were included in the group that received toceranib. There was no significant difference in survival time or PFI between the cats that did and did not receive toceranib when all cats were considered. When comparing only the cats with lingual tumors the PFI was significantly longer in the cats who received toceranib than those that did not (142 days vs 104 days, respectively P= 0.045) but there was no difference in MST (197 days vs 147 days P= 0.15). Additionally, among the cats who received toceranib there were significant differences in PFI and MST based on the location of the tumor. This study suggests that there may be clinical benefit to administering follow up toceranib after radiation in cats with lingual squamous cell carcinomas and additional prospective studies are warranted.
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Details
- Title
- THE EFFECT OF FOLLOW UP TOCERANIB PHOSPHATE ON FELINE ORAL SQUAMOUS CELL CARCINOMAS TREATED WITH HYPERFRACTIONATED RADIATION AND CARBOPLATIN
- Creators
- Andrew H. Schlueter
- Contributors
- Janean Fidel (Chair)Rance Sellon (Committee Member)Jeffrey Abbott (Committee Member)
- Awarding Institution
- Washington State University
- Academic Unit
- College of Veterinary Medicine
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University
- Number of pages
- 24
- Identifiers
- 99901152215801842
- Language
- English
- Resource Type
- Thesis