Thesis
TNF[alpha] G308A Polymorphism Is Associated with Resilience to Performance Impairment During Total Sleep Deprivation and Increased Delta and Theta Spectral Power in the Non-REM Sleep EEG
Master of Science (MS), Washington State University
01/2021
Handle:
https://hdl.handle.net/2376/124626
Abstract
There are large, trait-like individual differences in neurobehavioral performance impairment during total sleep deprivation (TSD). The A allele of the TNFα G308A polymorphism has been shown to confer resilience to performance impairment at baseline and during TSD. However, the underlying mechanisms of this association remain unclear. Here, we investigated differences in the sleep EEG of TNFα genotypes to shed light on a possible mechanism. N = 168 healthy young adults (ages 27.36 ± 5.38; 86 females, 82 males) participated in one of seven in-laboratory studies with 36 to 62 hours of TSD. Each period of TSD was preceded by one or two 10–12-hour baseline sleep periods. During TSD, vigilant attention was assessed every 2-3 hours with a psychomotor vigilance test (PVT). Following TSD, subjects had one or two 10–12-hour recovery sleep periods. Each sleep period was recorded polysomnographically. The EEG of stages N2 and N3 non-REM sleep were analyzed using spectral analysis to assess differences in delta and theta power bands. PVT lapses (RTs > 500 ms) were used to quantify neurobehavioral impairment.
The distribution of genotypes in this sample was found to be in Hardy-Weinberg equilibrium. In line with previous findings, carriers of the A allele exhibited fewer PVT lapses at baseline and during TSD compared to individuals homozygous for the G allele. During baseline and recovery sleep periods, individuals homozygous for the G allele displayed significantly increased delta and theta power.
Our results suggest that the performance vulnerability observed in individuals homozygous for the G allele may be driven by underlying differences in the homeostatic build up for sleep, which is reflected in delta and theta power of the sleep EEG. Individuals homozygous for the G allele may operate at a higher homeostatic setpoint, resulting in less-than-optimal performance under well-rested conditions that is further amplified during TSD.
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Details
- Title
- TNF[alpha] G308A Polymorphism Is Associated with Resilience to Performance Impairment During Total Sleep Deprivation and Increased Delta and Theta Spectral Power in the Non-REM Sleep EEG
- Creators
- Lillian Skeiky
- Contributors
- Hans P.A. Van Dongen (Co-Chair) - Washington State University, Department of Biomedical SciencesJohn M Hinson (Co-Chair) - Washington State University, Department of PsychologyPaul Michael Whitney (Committee Member) - Washington State University, Office of International ProgramsJonathan Wisor (Committee Member) - Washington State University, Department of Biomedical Sciences
- Awarding Institution
- Washington State University
- Academic Unit
- Department of Psychology
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Number of pages
- 48
- Identifiers
- 99900592256901842
- Language
- English
- Resource Type
- Thesis