Thesis
The antinociceptive and tolerance effects of morphine and bicuculline in the periaqueductal gray during chronic pain
Washington State University
Master of Science (MS), Washington State University
2011
Handle:
https://hdl.handle.net/2376/102096
Abstract
Morphine produced acute antinociception in both CFA and non-CFA animals, but did not cause tolerance development in either group. Bicuculline was also found to be antinociceptive in both groups, but the antinociception was attenuated only in the non-CFA rats pretreated with bicuculline. These results suggest that both morphine and bicuculline produce antinociception during chronic pain and acute pain. Pharmacological tolerance does not occur for morphine, but some evidence of tolerance can be seen for bicuculline. However, the results in this study were confounded by the presence of behavioral tolerance and therefore additional experiments are needed to verify the results.
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Details
- Title
- The antinociceptive and tolerance effects of morphine and bicuculline in the periaqueductal gray during chronic pain
- Creators
- Melissa L. Mehalick
- Contributors
- Michael Morgan (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Psychology, Department of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; Pullman, Wash. :
- Identifiers
- 99900525030601842
- Language
- English
- Resource Type
- Thesis