Thesis
Titanium oxide nanotube and calcium phosphate on modified titanium surface for drug delivery
Washington State University
Master of Science (MS), Washington State University
2013
Handle:
https://hdl.handle.net/2376/102518
Abstract
The objective of this study is to modify Titanium (Ti) surface with titanium oxide nanotube by anodization process and calcium phosphate by biomimetic and induction plasma spray to perform drug delivery. In the first part of the study anodization process was used to form titanium oxide nanotube followed by Hydroxyapatite coating and Gentamicin as an antibiotic drug delivery. Titanium is a bioinert material and, therefore, gets encapsulated after implantation into the living body by a fibrous tissue that isolates them from the surrounding tissues. In this work, titanium oxide layers were grown on commercially pure titanium substrate by anodization process using different electrolyte solutions namely (1) 1 v/v% HF, (2) 1.0 M H2SO4 with 0.1 M HF and (3) 0.25 wt% NH4F with ethylene glycol 10% DI water, (4) aqueous solution of 0.2 M citric acid, 0.1 M hydrofluoric acid and 1.0 M sulfuric acid. With 1 v/v% HF as an electrolyte the anodization process produced bioactive TiO2 films with a nanoporous structure at 20 V for 40 minutes. Cross-sectional view of the nanoporous surface reveals titanium oxide nanotubes of diameter 100 20 nm and length 400 100 nm. It was found that increasing anodization time Gentamicin was uploaded to the samples by applying the gentamicin aqueous solution followed by drying under vacuum infiltration. Drug release kinetics was studied and also Human osteoblast (HOB) cell attachment and growth behavior were studied using an osteoprecursor cell line (OPC 1) for 3, 7 and 11 days. In the second part of this study, radio frequency induction plasma spray was used to prepare HAp and doped HAp coatings on commercial pure titanium with improved crystallinity and phase purity. Hydroxyapatite plasma sprayed samples were loaded with 200 µg of alendronate sodium for each sample, and then the samples were coated with Polycaprolactone as a biodegradable polymer to reduce the drug release rate. These modified titanium surface implants have the potential to be used in load bearing application as well as drug delivery system in the term of a multifunctional device.
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Details
- Title
- Titanium oxide nanotube and calcium phosphate on modified titanium surface for drug delivery
- Creators
- Khalid Emshadi
- Contributors
- Susmita Bose (Degree Supervisor)
- Awarding Institution
- Washington State University
- Academic Unit
- Mechanical and Materials Engineering, School of
- Theses and Dissertations
- Master of Science (MS), Washington State University
- Publisher
- Washington State University; [Pullman, Washington] :
- Identifiers
- 99900525062901842
- Language
- English
- Resource Type
- Thesis