Journal article
A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
Cancer informatics, Vol.3, pp.117693510700300-274
01/2007
Handle:
https://hdl.handle.net/2376/104825
PMID: 19455246
Abstract
The Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC, http://www.pcabc.upmc.edu) is one of the first major project-based initiatives stemming from the Pennsylvania Cancer Alliance that was funded for four years by the Department of Health of the Commonwealth of Pennsylvania. The objective of this was to initiate a prototype biorepository and bioinformatics infrastructure with a robust data warehouse by developing a statewide data model (1) for bioinformatics and a repository of serum and tissue samples; (2) a data model for biomarker data storage; and (3) a public access website for disseminating research results and bioinformatics tools. The members of the Consortium cooperate closely, exploring the opportunity for sharing clinical, genomic and other bioinformatics data on patient samples in oncology, for the purpose of developing collaborative research programs across cancer research institutions in Pennsylvania. The Consortium’s intention was to establish a virtual repository of many clinical specimens residing in various centers across the state, in order to make them available for research. One of our primary goals was to facilitate the identification of cancer-specific biomarkers and encourage collaborative research efforts among the participating centers.
The PCABC has developed unique partnerships so that every region of the state can effectively contribute and participate. It includes over 80 individuals from 14 organizations, and plans to expand to partners outside the State. This has created a network of researchers, clinicians, bioinformaticians, cancer registrars, program directors, and executives from academic and community health systems, as well as external corporate partners - all working together to accomplish a common mission.
The various sub-committees have developed a common IRB protocol template, common data elements for standardizing data collections for three organ sites, intellectual property/tech transfer agreements, and material transfer agreements that have been approved by each of the member institutions. This was the foundational work that has led to the development of a centralized data warehouse that has met each of the institutions’ IRB/HIPAA standards.
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Details
- Title
- A Novel Cross-Disciplinary Multi-Institute Approach to Translational Cancer Research: Lessons Learned from Pennsylvania Cancer Alliance Bioinformatics Consortium (PCABC)
- Creators
- Ashokkumar A Patel - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstituteAndrea Lazarus - Pennsylvania State Cancer Institute at Milton S. Hershey Medical CenterJohn R Gilbertson - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstitutePhilip Lazarus - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalLouise C Showe - The Wistar InstituteJack W London - Kimmel Cancer Center of Thomas Jefferson UniversityEric Ross - Fox Chase Cancer CenterMichael F Ochs - Fox Chase Cancer CenterJoseph Carver - Abramson Cancer Center of the University of PennsylvaniaAnil V Parwani - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstituteRajiv Dhir - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstituteJ. Robert Beck - Fox Chase Cancer CenterMichael Liebman - Windber Research InstituteFernando U Garcia - Drexel University College of MedicineJeff Prichard - Geisinger Health SystemMyra Wilkerson - Geisinger Health SystemRonald B Herberman - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstituteMichael J Becich - Center for Pathology Informatics, Benedum Oncology Informatics Center, University of Pittsburgh Cancer InstituteNancy Whelan - University of Pittsburgh Cancer InstituteLois Mathews - University of Pittsburgh Cancer InstituteSharon Winters - University of Pittsburgh Cancer InstituteSusan Urda - University of Pittsburgh Cancer InstituteHeidi Gianella - University of Pittsburgh Cancer InstituteMichelle Bisceglia - University of Pittsburgh Cancer InstituteRajnish Gupta - University of Pittsburgh Cancer InstituteHarpreet Singh - University of Pittsburgh Cancer InstituteSonghui Li - University of Pittsburgh Cancer InstituteYimin Nie - University of Pittsburgh Cancer InstituteVicky Chu - University of Pittsburgh Cancer InstituteSambit Mohanty - University of Pittsburgh Cancer InstituteDorothy Mann - University of Pittsburgh Cancer InstituteLinda Mignogna - University of Pittsburgh Cancer InstituteFederico Monzon Bordonaba - University of Pittsburgh Cancer InstituteAlice Katsur - University of Pittsburgh Cancer InstituteJohn Kirkwood - University of Pittsburgh Cancer InstituteAdam Brufsky - University of Pittsburgh Cancer InstituteTheresa Colecchia - University of Pittsburgh Cancer InstituteCarolyn Green - University of Pittsburgh Cancer InstituteJohn Glick - Abramson Cancer Center of the University of PennsylvaniaJesse Tigges - Abramson Cancer Center of the University of PennsylvaniaDavid Fenstermacher - Abramson Cancer Center of the University of PennsylvaniaTimothy R Rebbeck - Abramson Cancer Center of the University of PennsylvaniaAngela DeMichele - Abramson Cancer Center of the University of PennsylvaniaBarbara Weber - Abramson Cancer Center of the University of PennsylvaniaDuPont Guerry - Abramson Cancer Center of the University of PennsylvaniaElizabeth Poppert - Abramson Cancer Center of the University of PennsylvaniaKate Haney - Fox Chase Cancer CenterSteve Brusstar - Fox Chase Cancer CenterJohn Malick - Fox Chase Cancer CenterArlene Capriotti - Fox Chase Cancer CenterAndrew Balshem - Fox Chase Cancer CenterRobert G Uzzo - Fox Chase Cancer CenterLori J Goldstein - Fox Chase Cancer CenterStuart R Lessin - Fox Chase Cancer CenterPat Harsche - Fox Chase Cancer CenterW.Thomas London - Fox Chase Cancer CenterRichard L Davidson - Kimmel Cancer Center of Thomas Jefferson UniversityMonica deBaca - Kimmel Cancer Center of Thomas Jefferson UniversityAlejandra Ruiz Orrico - Kimmel Cancer Center of Thomas Jefferson UniversityAdler Hannes - Kimmel Cancer Center of Thomas Jefferson UniversityJuan P Palazzo - Kimmel Cancer Center of Thomas Jefferson UniversityAdam Dicker - Kimmel Cancer Center of Thomas Jefferson UniversityMichael Mastrangelo - Kimmel Cancer Center of Thomas Jefferson UniversityKatherine Chou - Kimmel Cancer Center of Thomas Jefferson UniversityThomas Loughran - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalPam Whayland - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalPat Swetland - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalIsom Harriet - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalDan Beard - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalAlan J Snyder - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalWitold B Rybka - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalDaniel Lorence - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalAllan Lipton - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalHarold A Harvey - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalGavin Robertson - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalDavid Claxton - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalRichard Rauscher - Pennsylvania State Cancer Institute at Milton S. Hershey MedicalJenine Carlisle - The Wistar InstituteRussel E Kaufman - The Wistar InstituteDonald Ewert - The Wistar InstituteElizabeth O'Brien - The Wistar InstituteMeryle Melnicoff - The Wistar InstituteKenneth Blank - Drexel University College of MedicineTesfu Hailu - Drexel University College of MedicineSokol Petushi - Drexel University College of MedicineGlenn D Steele - Geisinger Health SystemSandy Buckley - Geisinger Health SystemNicole Hunter - Geisinger Health SystemKim Yantus - Windber Research InstituteHai Hu - Windber Research InstituteChris Sheridan - Windber Research InstituteHolly Rigby - Windber Research InstituteF. Nicholas Jacobs - Windber Research InstitutePat Bronder - Pittsburgh Life Sciences GreenhouseDavid Palmer - Pittsburgh Life Sciences GreenhouseJohn H Glick - Pittsburgh Life Sciences Greenhouse
- Publication Details
- Cancer informatics, Vol.3, pp.117693510700300-274
- Academic Unit
- Pharmaceutical Sciences, Department of
- Identifiers
- 99900546547901842
- Language
- English
- Resource Type
- Journal article