Journal article
A Novel Type of Sequence Variation: Multiple-Nucleotide Length Polymorphisms Discovered in the Bovine Genome
Genetics (Austin), Vol.176(1), pp.403-407
05/2007
Handle:
https://hdl.handle.net/2376/115223
PMCID: PMC1893069
PMID: 17409076
Abstract
Three types of sequence variations—single-nucleotide polymorphisms (SNPs), insertions and deletions (indels), and short tandem repeats (STRs)—have been extensively reported in mammalian genomes. In this study, we discovered a novel type of sequence variation,
i.e
., multiple-nucleotide length polymorphisms (MNLPs) in bovine
UCN3
(Urocortin 3) and its receptor
CRHR2
(corticotropin-releasing hormone receptor 2) genes. Both MNLPs featured involvement of multiple-nucleotide length polymorphisms (5–18 bases), low sequence identity, and 1.7- to 11-fold changes in promoter activity between two alleles. Therefore, this novel genetic complexity would contribute significantly to the evolutionary, functional, and phenotypic complexity of genomes within or among species.
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Details
- Title
- A Novel Type of Sequence Variation: Multiple-Nucleotide Length Polymorphisms Discovered in the Bovine Genome
- Creators
- Zhihua Jiang - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Zeping Wang - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Tanja Kunej - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Galen A Williams - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Jennifer J Michal - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Xiao-Lin Wu - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351Nancy S Magnuson - Department of Animal Sciences, Washington State University, Pullman, Washington 99164-6351
- Publication Details
- Genetics (Austin), Vol.176(1), pp.403-407
- Academic Unit
- Molecular Biosciences, School of; Animal Sciences, Department of
- Publisher
- Copyright © 2007 by the Genetics Society of America
- Number of pages
- 5
- Identifiers
- 99900548326201842
- Language
- English
- Resource Type
- Journal article