A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

Anna C Need; Deborah K Attix; Jill M McEvoy; Elizabeth T Cirulli; Kristen L Linney; Priscilla Hunt; Dongliang Ge; Erin L Heinzen; Jessica M Maia; Kevin V Shianna; Michael E Weale; Lynn F Cherkas; Gail Clement; Tim D Spector; Greg Gibson; David B Goldstein

doi:10.1093/hmg/ddp413

Back

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

Journal article

Open access

Peer reviewed

A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB

Anna C Need, Deborah K Attix, Jill M McEvoy, Elizabeth T Cirulli, Kristen L Linney, Priscilla Hunt, Dongliang Ge, Erin L Heinzen, Jessica M Maia, Kevin V Shianna, …

Human molecular genetics, Vol.18(23), pp.4650-4661

12/01/2009

DOI: https://doi.org/10.1093/hmg/ddp413

Handle:

https://hdl.handle.net/2376/104149

PMCID: PMC2773267

PMID: 19734545

Files and links (2)

pdf

ddp413228.21 kBDownload View

Open Access

url

https://doi.org/10.1093/hmg/ddp413View

Published (Version of record) Open

Abstract

Association Studies

Psychiatric disorders such as schizophrenia are commonly accompanied by cognitive impairments that are treatment resistant and crucial to functional outcome. There has been great interest in studying cognitive measures as endophenotypes for psychiatric disorders, with the hope that their genetic basis will be clearer. To investigate this, we performed a genome-wide association study involving 11 cognitive phenotypes from the Cambridge Neuropsychological Test Automated Battery. We showed these measures to be heritable by comparing the correlation in 100 monozygotic and 100 dizygotic twin pairs. The full battery was tested in ∼750 subjects, and for spatial and verbal recognition memory, we investigated a further 500 individuals to search for smaller genetic effects. We were unable to find any genome-wide significant associations with either SNPs or common copy number variants. Nor could we formally replicate any polymorphism that has been previously associated with cognition, although we found a weak signal of lower than expected P -values for variants in a set of 10 candidate genes. We additionally investigated SNPs in genomic loci that have been shown to harbor rare variants that associate with neuropsychiatric disorders, to see if they showed any suggestion of association when considered as a separate set. Only NRXN1 showed evidence of significant association with cognition. These results suggest that common genetic variation does not strongly influence cognition in healthy subjects and that cognitive measures do not represent a more tractable genetic trait than clinical endpoints such as schizophrenia. We discuss a possible role for rare variation in cognitive genomics.

Metrics

19 Record Views

See more details

Details

Title: A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
Creators: Anna C Need
Deborah K Attix - Duke University Medical Center
Jill M McEvoy
Elizabeth T Cirulli
Kristen L Linney
Priscilla Hunt - Gardner Hall, North Carolina State University
Dongliang Ge
Erin L Heinzen
Jessica M Maia
Kevin V Shianna - Duke University
Michael E Weale - King's College London
Lynn F Cherkas - King's College London
Gail Clement - King's College London
Tim D Spector - King's College London
Greg Gibson - Gardner Hall, North Carolina State University
David B Goldstein
Publication Details: Human molecular genetics, Vol.18(23), pp.4650-4661
Academic Unit: Elson S. Floyd College of Medicine
Publisher: Oxford University Press
Number of pages: 12
Identifiers: 99900546996101842
Language: English
Resource Type: Journal article