Journal article
A local, bottom-up perspective on sleep deprivation and neurobehavioral performance
Current topics in medicinal chemistry, Vol.11(19), pp.2414-2422
2011
Handle:
https://hdl.handle.net/2376/115097
PMCID: PMC3243827
PMID: 21906023
Abstract
Waking neurobehavioral performance is temporally regulated by a sleep/wake homeostatic process and a circadian process in interaction with a time-on-task effect. Neurobehavioral impairment resulting from these factors is task-specific, and characterized by performance variability. Several aspects of these phenomena are not well understood, and cannot be explained solely by a top-down (subcortically driven) view of sleep/wake and performance regulation. We present a bottom-up theory, where we postulate that task performance is degraded by local, use-dependent sleep in neuronal groups subserving cognitive processes associated with the task at hand. The theory offers explanations for the temporal dependence of neurobehavioral performance on time awake, time on task, and their interaction; for the effectiveness of task switching and rest breaks to overcome the time-on-task effect (but not the effects of sleep deprivation); for the task-specific nature of neurobehavioral impairment; and for the stochastic property of performance variability.
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Details
- Title
- A local, bottom-up perspective on sleep deprivation and neurobehavioral performance
- Creators
- Hans P A Van Dongen - Sleep and Performance Research Center and Neuroscience Program, Washington State University, Spokane, WA 99210-1495, USAGregory BelenkyJames M Krueger
- Publication Details
- Current topics in medicinal chemistry, Vol.11(19), pp.2414-2422
- Academic Unit
- Medical Education and Clinical Science, Department of; Integrative Physiology and Neuroscience, Department of
- Publisher
- United Arab Emirates
- Grant note
- R01 NS025378 / NINDS NIH HHS R01 NS031453-18 / NINDS NIH HHS R01 NS031453 / NINDS NIH HHS R01 NS025378-25 / NINDS NIH HHS
- Identifiers
- 99900548353001842
- Language
- English
- Resource Type
- Journal article