Journal article
A low-cost telemetry system suitable for measuring mouse biopotentials
Medical engineering & physics, Vol.30(2), pp.199-205
2008
Handle:
https://hdl.handle.net/2376/111062
PMID: 17403611
Abstract
The ability to generate specific genetic mutations in mice is a powerful tool to study normal and pathophysiological function. In order to determine the effects of a mutation, measurement of physiological variables, such as biopotentials, is often necessary. However, such measurements can be particularly challenging to obtain from an awake, unrestrained mouse. The goal of this study was to design and implement a telemetry system suitable for recording biopotentials from a mouse. A battery-powered system was fabricated from commercially available electronic components mounted on a small circuit board. The frequency response of the system was measured over a range of frequencies and found suitable for recording biopotentials in mice and larger animals. We affixed the circuit board externally to a mouse and connected surface electrodes to measure electrocardiograms (ECG). The size and weight of the board did not disturb normal behavior over 30–60
min. Recorded ECGs had easily identifiable components relevant to physiological parameters and had a similar frequency spectrum compared to recordings obtained from a commercially available measurement system. In conclusion, the telemetry system was low-cost due to the availability of the components, straightforward to implement, and provided biopotential recordings suitable for measuring physiological parameters in an awake mouse.
Metrics
7 Record Views
Details
- Title
- A low-cost telemetry system suitable for measuring mouse biopotentials
- Creators
- David C Lin - Program in Bioengineering, Washington State University, P.O. Box 646520, Pullman, WA 99164, United StatesBrandon P Bucher - Program in Bioengineering, Washington State University, P.O. Box 646520, Pullman, WA 99164, United StatesHoward P Davis - Program in Bioengineering, Washington State University, P.O. Box 646520, Pullman, WA 99164, United StatesLeslie K Sprunger - Program in Neuroscience, Washington State University, Pullman, WA 99164, United States
- Publication Details
- Medical engineering & physics, Vol.30(2), pp.199-205
- Academic Unit
- Veterinary Medicine, College of; Chemical Engineering and Bioengineering, School of
- Publisher
- Elsevier Ltd
- Identifiers
- 99900546910601842
- Language
- English
- Resource Type
- Journal article