Journal article
A peroxidase-like single-atom Fe-N5 active site for effective killing human lung adenocarcinoma cells
Nano research, Vol.16(4), pp.5216-5225
04/01/2023
Abstract
Single-atom catalyst (SAC) is one of the newest catalysts, and attracts people's wide attention in cancer therapy based on their characteristics of maximum specific catalytic activity and high stability. We designed and synthesized a Fe-N decorated graphene nanosheet (Fe-N-5/GN SAC) with the coordination number of five. Through enzymology and theoretical calculations, the Fe-N-5/GN SAC has outstanding intrinsic peroxidase-like catalytic activity due to single-atom Fe site with five-N-coordination structure. We explored its potential on lung cancer therapy, and found that it could kill human lung adenocarcinoma cells (A549) by decomposing hydrogen peroxide (H2O2) into toxic reactive oxygen species (ROS) under acidic microenvironment in three-dimensional (3D) lung cancer cell model. Our study demonstrates a promising application of SAC with highly efficient single-atom catalytic sites for cancer treatment.
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Details
- Title
- A peroxidase-like single-atom Fe-N5 active site for effective killing human lung adenocarcinoma cells
- Creators
- Liye Zhu - China Agricultural UniversityHong Zhong - Washington State UniversityDan Du - Washington State UniversityTao Li - Northern Illinois UniversityHoai Nguyen - Argonne National LaboratoryScott P. Beckman - Washington State UniversityWentao Xu - China Agricultural UniversityJin-Cheng Li - Kunming UniversityNan Cheng - China Agricultural UniversityYuehe Lin - Washington State University
- Publication Details
- Nano research, Vol.16(4), pp.5216-5225
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Tsinghua Univ Press
- Number of pages
- 10
- Grant note
- 2115 Talent Development Program of China Agricultural University DE-AC02-06CH11357 / DOE Office of Science; United States Department of Energy (DOE)
- Identifiers
- 99901227643701842
- Language
- English
- Resource Type
- Journal article