Journal article
A review on emerging principles and strategies for colorimetric and fluorescent detection of alkaline phosphatase activity
Analytica chimica acta, Vol.1086, pp.29-45
12/04/2019
PMID: 31561792
Abstract
Alkaline phosphatase (ALP) is a natural enzyme that is able to catalyze the dephosphorylation of phosphate esters. It participates in a great number of biological processes ranging from various metabolisms to signal transduction and cellular regulation. Since the abnormality of ALP activity in body is closely associated with many diseases, it has become an important biomarker for clinical diagnosis and treatment. Besides, it is often utilized in enzyme-linked immunosorbent assays. Given these demands, in the last few years considerable interest has been focused on exploring new materials and methods for ALP activity detection. In this review, we first made a clear classification on the principles that could be used for ALP activity determination. After that, emerging colorimetric and fluorescent strategies designed on the basis of these principles were systematically summarized. Finally, some perspectives on ALP activity analysis were discussed, hoping to inspire future efforts in the field. (C) 2019 Elsevier B.V. All rights reserved.
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Details
- Title
- A review on emerging principles and strategies for colorimetric and fluorescent detection of alkaline phosphatase activity
- Creators
- Xiangheng Niu - Jiangsu UniversityKun Ye - Jiangsu UniversityLinjie Wang - Jiangsu UniversityYuehe Lin - Washington State UniversityDan Du - Washington State University
- Publication Details
- Analytica chimica acta, Vol.1086, pp.29-45
- Academic Unit
- School of Mechanical and Materials Engineering
- Publisher
- Elsevier
- Number of pages
- 17
- Grant note
- BK20160489 / Natural Science Foundation of Jiangsu Province 21605061 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) Project for Outstanding Young Teachers of Jiangsu University
- Identifiers
- 99901227638901842
- Language
- English
- Resource Type
- Journal article